Not every adult with ADHD should take a stimulant, and not every adult wants to. Non-stimulant medications are effective, are not controlled substances, and work around the clock once they take effect.
Atomoxetine (Strattera)
A norepinephrine reuptake inhibitor approved for adult ADHD. It builds up over four to eight weeks, so patience matters. Common side effects include nausea, lower appetite, trouble sleeping or drowsiness, and in some men urinary or sexual side effects.
Viloxazine (Qelbree)
Approved for adults in 2022. It may start helping within a few weeks. Common side effects include sleepiness, headache, nausea and insomnia. It interacts with some other medicines, so share your full medication list with your prescriber.
Other options
- Bupropion (Wellbutrin): used off-label, especially when depression is also present
- Guanfacine extended-release (Intuniv) and clonidine extended-release: approved for children and sometimes used in adults, alone or with a stimulant
Good candidates for a non-stimulant
Adults with anxiety that stimulants worsen, a history of substance use, or who simply prefer a non-controlled option. Atomoxetine and viloxazine can also raise heart rate and blood pressure, so every ADHD medicine, stimulant or not, needs a heart review first.
A safety note
Atomoxetine and viloxazine carry a warning about suicidal thoughts in children and young adults. Report any worsening mood promptly.
Get help from Hope Integrative Medicine
If you want to explore a non-stimulant ADHD medication, we can help you decide whether it fits. Our mental health team sees patients in person in West Ashley and by telehealth across South Carolina, and new patients are often able to be scheduled within a week of requesting an appointment. Request an appointment.
This article is general health information and does not replace advice from your own provider. Never start, stop or change a medication without talking with your prescriber. If you are having thoughts of harming yourself, call or text 988 or call 911.
Frequently Asked Questions
Atomoxetine (Strattera) builds up gradually and usually takes four to eight weeks to reach its full effect.
Yes. Viloxazine (Qelbree) was approved for adult ADHD in 2022.
No. Strattera, Qelbree, bupropion and guanfacine are not controlled substances, so refills are simpler and they are not affected by stimulant supply limits.